This protocol addressed hyperinflammation, hypercoagulation and hypoxia, the three mechanisms that make COVID lethal. Its name is derived from intravenous Methylprednisolone, high-dose intravenous Ascorbic acid (vitamin C), optional additions including Thiamine, zinc and vitamin D, and full-dose, low molecular weight Heparin. The MATH+ protocol is designed to treat the active phase of COVID infection, called the hyperinflammatory immune response, which can result in organ failures, but it needs to be administered early enough. These three medicines should be started within six hours of hospital admission:
- Intravenous methylprednisolone to suppress the immune system and prevent organ damage from cytokine storms. On Day 8, switch to oral prednisone and taper down over the next six days.
- Intravenous ascorbic acid (vitamin C) to control inflammation and prevent the development of leaky blood vessels in the lungs.
- Subcutaneous heparin (enoxaparin) to thin the blood and prevent blood clots.
Optional additions include thiamine, zinc and vitamin D. The protocol also calls for high-flow nasal oxygen to avoid mechanical ventilation.